The FDA states on their website that the claim that bioidentical hormones are safer and more effective than synthetic menopausal hormone replacement therapy is a “myth” and that there is no scientific evidence for these claims.

In response, we offer a working, curated collection of articles that review the medical literature and scientific evidence pertaining to the increased efficacy and safety profile of bioidentical hormone replacement therapy. Note that review articles contain references to the primary scientific studies. Review and decide for yourself.

1) Bioidentical Hormones: Why are they Still Controversial?

2) The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?

3) A Comprehensive Review of the Safety and Efficacy of Bioidentical Hormones for the Management of Menopause and Related Health Risks